The Modern Concept of Uræmia and Its Clinical Study. (Based on a Series of Forty-Four Cases)

Although the term uraemia was first introduced in 1840 by Piorry and L'Heritier, its true nature was disclosed by the work of Widal and Javal (1903). Bright, as early as 1833, though the term uraemia was unknown, recognized that the impregnation of the circulating blood with demonstrable amounts of urea was in some way responsible for a general derangement of the constitution. It is somewhat difficult to define the term uraemia accurately. Dr. Izod Bennet defined it as a physical disturbance resulting from renal failure of a severe degree. Such a physical disturbance comprises a group of symptoms which